Biomaterials play an important role in Therapeutic Delivery like Biocompatible polymeric gene carriers which have been introduced for treating diverse genetic and acquired diseases. The researchers are working on the biomaterial approaches to significantly improve outcomes of gene #therapies for neurodegenerative disorders. The Nanobiomaterial architecture is the basis for fabrication of novel integrated systems involving cells, growth factors, proteins, cytokines, drug molecules, and other biomolecules with the rationale of creating a universal, all-purpose Nano-biomedical device for personalized therapies.